You have many options if you think you need antidepressants. They’re generally safe, well-studied, and may help improve your quality of life. Speak with your doctor about possible side effects, like weight loss or gain.
Some may be unsure about antidepressants or have concerns about side effects, psychological dependence, or addiction. Yet, antidepressants may help many people through different phases of depression.
Deciding to use an antidepressant as a treatment option is a personal decision involving a collaborative effort with your doctor. Doing your research, learning more about antidepressants, and talking with your doctor can help you make a choice that’s right for you.
Antidepressants are medications used to
- affect neurotransmitters
- reduce the biological impact of stress on the brain
- increase the brain’s capacity to cope with future stress
Many kinds of antidepressants are available. Common classes of antidepressants used to help treat depression include:
- selective serotonin reuptake inhibitors (SSRIs)
- serotonin and norepinephrine reuptake inhibitors (SNRIs)
- tricyclic antidepressants
- noradrenergic and dopamine reuptake blocker
- monoamine oxidase inhibitors (MAOIs)
Learn more about antidepressant medications.
Taking antidepressants has many benefits. Knowing these can help inform your decision.
They’re effective at relieving symptoms
Research suggests that antidepressants may be more
They’re well-studied and generally safe
The Food and Drug Administration (FDA)
They may help you succeed with other parts of your treatment plan
Your treatment plan may include other aspects, like lifestyle changes or therapy.
If your depression makes you apathetic and lethargic, antidepressants can help restore your energy so you can:
- fulfill everyday activities
- participate in therapy
- complete other items in your treatment plan
Improved quality of life
People on antidepressants report an
- are less reactive to negative life events
- can examine things in a more balanced way
- have improved concentration
If you think you need antidepressants
Finding treatment for depression is a big step and isn’t always easy. If you think you need antidepressants:
- Talk with your doctor: They can screen for depression and talk about your symptoms to evaluate your situation. Some can prescribe antidepressants. Others may prescribe them and refer you to a counselor for talk therapy.
- Ask your doctor for a referral to a psychiatrist: This is especially important if your depression is severe or you have other medical or mental health conditions.
These organizations can help you find a psychiatrist or mental health professional:
- American Psychiatric Association’s (APA) Find a Psychiatrist search
- Substance Abuse and Mental Health Services Administration helpline
- Anxiety & Depression Association of America Find a Therapist Directory
- Black Mental Health Alliance’s Connect with a Therapist search
- American Society of Hispanic Psychiatry’s Find a Physician search
- World Professional Association for Transgender Health’s (WPATH) provider directory
As with any medication, antidepressants may have cons. These may vary for everyone, but knowing them can help you prepare.
Talking with your doctor about any drawbacks can help determine whether the pros outweigh the cons.
You may need to try several kinds
Not every antidepressant will work for everyone. You might have to switch more than once to find the best medication for you and your symptoms.
Antidepressants can also take some time to reach their full effect.
They may affect your sex drive
Antidepressants may reduce your sex drive or sexual functioning. Some antidepressants are more likely than others to do so.
If the side effects interfere with your life, ask your doctor about adjusting the dosage or finding other ways to manage them.
Learn more about managing the sexual side effects of antidepressants.
They can affect sleep
Disrupted sleep is common among people with depression, but it’s usually not clear whether it’s a side effect of medication or a symptom of depression. If you have a sleep disorder, this can further affect your sleep.
Some antidepressants have sleep-related (sedating) effects, such as:
- fluvoxamine
- mirtazapine
- trazodone (only prescribed for sleep)
- paroxetine
Antidepressants may also contribute to insomnia, depending on:
- the antidepressant
- the dosage
- when you take it
If your antidepressant is interfering with your sleep, talk with your doctor.
They may affect your weight
Some antidepressants list weight gain as a side effect, but other antidepressants carry a lower risk of weight gain. This doesn’t mean you will gain or lose weight on antidepressants. Everyone’s bodies respond to them differently.
The potential for weight gain shouldn’t control your decision about antidepressants.
Learn more about antidepressant-related weight gain and weight loss.
They may be costly
Even with insurance and generic prescriptions, antidepressants might still be costly.
Although your insurance provider and plan determine the prescription cost, it may be beneficial to work with your doctor to see if they can:
- provide an authorization request to your insurance company
- help you find a more affordable option
- offer you samples or coupons
Learn about medicare coverage for antidepressants.
They may have side effects
Side effects can be troublesome. They may include:
These minor side effects tend to pass within a few weeks. If you continue to have side effects or significant ones that don’t go away, talk with your doctor.
Learn more about the side effects of antidepressants.
If you choose to stop, you cannot stop abruptly
If you decide to stop taking antidepressants, abrupt stopping is not recommended, as withdrawal symptoms can occur.
Do not stop taking your medication until you’ve talked with your doctor. They might put you on a
Learn more about tapering off antidepressants.
Antidepressants are generally a safe and effective FDA-approved treatment option for depression. They may even help you succeed in other areas of your treatment plan. An improved quality of life may be on the other side of treatment.
Various classes of antidepressants are available, and different drugs are available within each class.
Finding the right antidepressant for you can take time, and you may face sexual side effects or weight loss or gain, among other side effects. You might have to try more than one before you find one that works best for you.